Hubei God bull Pharmaceutical Co.,Ltd

News

Formestane White Raw Powder CAS 566-48-3 Lentaron AI Anti Estrogen

Author : johns Date : 11/22/2016 12:10:09 AM
 Description :

 

1. Lentaron, a.k.a. formestane, belongs to a class of drugs known as 2 (or second generation) aromatase inhibitors which are primarily used in the treatment of estrogen-receptor positive breast and ovarian cancers in post-menopausal women.

 

2. Some cancers require estrogen to grow, and aromatase is an enzyme that synthesizes estrogen. Aromatase Inhibitors (AIs) are a class of drugs that effectively block this synthesis thereby lowering estrogenic levels, and slowing the growth of cancers.

 

3. AIs are categorized into two types: 1) non-steroidal inhibitors such as Arimidex (anastrozole) and Femera (Letrozole) which inhibit the enzyme by reversible competition and; 2) irreversible steroidal inhibitors such as Aromasin (exemestrane) which form a permanent bond with the aromatase enzyme complex.

 

4. Lentaron is classified in the second group as a selective irreversible steroidal aromatase inhibitor. Derived from androstenedione (the same except for the addition of a 4-hydroxyl group), formestane forms an irreversible bond with the aromatase enzyme which permanently deactivates it.

 

5. It takes several days (following formestane discontinuation) for aromatase to become active again. These types of drugs are often referred to as suicidal aromatase inhibitors because the drugs seemingly sacrifice themselves (their structural independence) in the process of blocking estrogen.